Keywords: Magnetic resonance imaging (MRI) low back pain (LBP) disc degeneration ultrashort echo time (UTE) adiabatic T 1ρ This is an advance, and of value for comprehensive assessment of IVD degeneration. T 1ρ differences of the outer posterior annulus fibrosis, inferior CEP, and NP between the subjects with and without LBP were significant (P=0.005, 0.020, and 0.000, respectively).Ĭonclusions: The UTE-Adiab-T 1ρ sequence can quantify T 1ρ of whole IVDs including CEPs. Correlations of T 1ρ values of the outer anterior annulus fibrosis, outer posterior annulus fibrosis, and NP with ages were significant with R equal to 0.52, 0.71, and −0.76, respectively.
Results: Correlations of T 1ρ values of the outer posterior annulus fibrosis, superior CEP, inferior CEP, and NP with modified Pfirrmann grades were significant (P<0.05) with R values of 0.51, 0.36, 0.38, and −0.94, respectively. In addition, T 1ρ values were compared in subjects with and without low back pain (LBP).
T 1ρ values of these sub-regions were correlated with IVD modified Pfirrmann grades and subjects’ ages. Each IVD was manually segmented into seven regions (i.e., outer anterior annulus fibrosis, inner anterior annulus fibrosis, outer posterior annulus fibrosis, inner posterior annulus fibrosis, superior CEP, inferior CEP, and NP). Methods: Seventeen subjects underwent UTE with adiabatic T 1ρ preparation (UTE-Adiab-T 1ρ) and T 2-weighted fast spin echo imaging of their lumbar spines. This can be overcome by using ultrashort echo time (UTE) T 1ρ acquisitions. However, no T 1ρ study of cartilaginous endplates (CEPs) has yet been reported because the relatively long echo times (TEs) of conventional clinical T 1ρ sequences cannot effectively capture the fast-decaying magnetic resonance signals of CEPs, which have very short T 2/T 2*s. Bydder 1, Wenhui Yang 2,3, Ya-Jun Ma 1ġ Department of Radiology, University of California San Diego, La Jolla, CA, USA Ģ Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China ģ University of Chinese Academy of Sciences, Beijing, China Ĥ Research Service, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA ĥ Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA Ħ Department of Orthopedic Surgery, University of California San Diego, La Jolla, CA, USAĬontributions: (I) Conception and design: YJ Ma (II) Administrative support: Z Wei, YJ Ma (III) Provision of study materials or patients: Z Wei, YJ Ma (IV) Collection and assembly of data: Z Wei (V) Data analysis and interpretation: Z Wei, AF Lombardi (VI) Manuscript writing: All authors (VII) Final approval of manuscript: All authors.īackground: T 1ρ has been extensively reported as a sensitive biomarker of biochemical changes in the nucleus pulposus (NP) and annulus fibrosis of intervertebral discs (IVDs). Lee 1, Mark Wallace 5, Koichi Masuda 6, Eric Y.
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